Design of a High-Throughput Flow Perfusion Bioreactor System for Tissue Engineering
نویسندگان
چکیده
منابع مشابه
Design of a flow perfusion bioreactor system for bone tissue-engineering applications.
Several different bioreactors have been investigated for tissue-engineering applications. Among these bioreactors are the spinner flask and the rotating wall vessel reactor. In addition, a new type of culture system has been developed and investigated, the flow perfusion culture bioreactor. Flow perfusion culture offers several advantages, notably the ability to mitigate both external and inter...
متن کاملDesign modification and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering
A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause-effect diagram as potential improvement opportunities. A screening process was use...
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Nutrient transport limitation remains a fundamental issue for in vitro culture of engineered tissues. In this study, perfusion bioreactor configurations were investigated to provide uniform delivery of oxygen to media equivalents (MEs) being developed as the basis for tissue-engineered arteries. Bioreactor configurations were developed to evaluate oxygen delivery associated with complete transm...
متن کاملDesign modi cation and optimisation of the perfusion system of a tri-axial bioreactor for tissue engineering
A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause–effect diagram as potential improvement opportunities. A screening process was use...
متن کاملDesign of a biaxial mechanical loading bioreactor for tissue engineering.
We designed a loading device that is capable of applying uniaxial or biaxial mechanical strain to a tissue engineered biocomposites fabricated for transplantation. While the device primarily functions as a bioreactor that mimics the native mechanical strains, it is also outfitted with a load cell for providing force feedback or mechanical testing of the constructs. The device subjects engineere...
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ژورنال
عنوان ژورنال: Tissue Engineering Part C: Methods
سال: 2012
ISSN: 1937-3384,1937-3392
DOI: 10.1089/ten.tec.2012.0037